Zygotic Associations and Multilocus Statistics in a Nonequilibrium Diploid Population
نویسندگان
چکیده
منابع مشابه
Zygotic associations and multilocus statistics in a nonequilibrium diploid population.
The usual approach to characterizing and estimating multilocus associations in a diploid population assumes that the population is in Hardy-Weinberg equilibrium. The purpose of this study is to develop a set of summary statistics that can be used to characterize and estimate the multilocus associations in a nonequilibrium population. The concept of "zygotic associations" is first expanded to fa...
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While nonrandom associations between zygotes at different loci (zygotic associations) frequently occur in Hardy-Weinberg disequilibrium populations, statistical analysis of such associations has received little attention. In this article, we describe the joint distributions of zygotes at multiple loci, which are completely characterized by heterozygosities at individual loci and various multilo...
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Recently founded populations represent an enormous challenge for genetic analysis: new populations are often genetically impoverished, making it hard to find sufficiently variable markers, and what little variation is present tends to be ancestral, rendering phylogenetic methods inappropriate. Recently, novel genetic markers and new statistical analyses have made multilocus genotyping an invalu...
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Malaria is an infectious disease that is caused by a group of parasites of the genus Plasmodium. Characterizing the association between polymorphisms in the parasite genome and measured traits in an infected human host may provide insight into disease aetiology and ultimately inform new strategies for improved treatment and prevention. This, however, presents an analytic challenge since individ...
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One crucial feature of zygotic linkage disequilibrium (LD) analysis is its direct use of diploid genotyping data, irrespective of the type of mating system. Previous theories from an evolutionary perspective mainly focus on gametic LD, but the equivalent development for zygotic LD is not available. Here I study the evolution of zygotic LD and the covariances between gametic and zygotic LDs or b...
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ژورنال
عنوان ژورنال: Genetics
سال: 2000
ISSN: 1943-2631
DOI: 10.1093/genetics/155.3.1449